N - acetylcysteine selectively antagonizes the activity of imipenem in 1 Pseudomonas aeruginosa by an OprD - mediated mechanism . 2 3 4
نویسندگان
چکیده
Pseudomonas aeruginosa by an OprD-mediated mechanism. 2 3 4 Jerónimo Rodríguez-Beltrán1,2, Gabriel Cabot3, Estela Ynés Valencia1,2,&, Coloma 5 Costas1,2, German Bou4, Antonio Oliver3 and Jesús Blázquez1,2 *. 6 7 8 1: Instituto de Biomedicina de Sevilla (IBIS), Consejo Superior de Investigaciones 9 Científicas (CSIC) and Universidad de Sevilla, Sevilla, Spain. 10 2: Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain. 11 3: Servicio de Microbiología and Unidad de Investigación, Hospital Universitario 12 Son Espases, Instituto de Investigación Sanitaria de Palma (IdISPa), Palma de 13 Mallorca, Spain. 14 4: Complejo Hospitalario Universitario A Coruña, A Coruña, Spain. 15 &: Present address: Department of Microbiology, Institute of Biomedical Sciences, 16 University of São Paulo, São Paulo, SP 05508-900, Brazil. 17 18 * Corresponding author. 19 Instituto de Biomedicina de Sevilla (IBIS). Campus Hospital Virgen del Rocío, Avda. 20 Manuel Siurot s/n, 41013-Sevilla, Spain. Phone: 34 955923135. E-mail: jblazquez21 [email protected] 22 and Centro Nacional de Biotecnología (CNB), Calle Darwin, 3, 28049-Madrid, Spain. 23 24
منابع مشابه
N-acetylcysteine selectively antagonizes the activity of imipenem in Pseudomonas aeruginosa by an OprD-mediated mechanism.
The modulating effect of N-acetylcysteine (NAC) on the activity of different antibiotics has been studied in Pseudomonas aeruginosa. Our results demonstrate that, in contrast to previous reports, only the activity of imipenem is clearly affected by NAC. MIC and checkerboard determinations indicate that the NAC-based modulation of imipenem activity is dependent mainly on OprD. SDS-PAGE of outer ...
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